Plinabulin at a glance

First-in-class, small-molecule immune modulator with a differentiated mechanism and emerging clinical benefits across selected tumor types.

Cancer Treatment
Anti-Cancer Efficacy

Targeting cancer indications for a potentially balanced efficacy versus safety profile better survival rates and better tolerability.

Safety Benefit
Safety Benefit

Significantly lower chemotherapy induced neutropenia from 6 clinical studies.

Plinabulin at a glance

Turning on the body’s own immune defenders.

Targeted immune pathways with the aim to improve overall survival rates and durability.

12+

Plinabulin has been tested in over 12 clinical studies from phase 1 to phase 3, and in investigator-initiated trials.

700+

Over 700 cancer patients have been treated with Plinabulin with good tolerability.

50%+

In various cancer types, Plinabulin combination with radiation and PD-1/PD-L1 inhibitors showed over 50% of disease control rate in cancer patients who failed prior immune checkpoint inhibitors.

Long-term OS benefit

In previously treated EGFR wild-type NSCLC (DUBLIN-3 phase 3 study), plinabulin sequentially administrated after docetaxel improves docetaxel tolerability and treatment duration with lower incidence of severe neutropenia in the first cycle. Importantly, the combination arm has nearly doubled 24- and 36- month OS rates with an mOS extension of 2.5 months in patients with non-squamous histology (The Lancet Respiratory Medicine 2024).

Leadership

Led by experienced oncology agent developers.

Meet the passionate team making it happen.

Partner with us

Collaborate to accelerate development & expand impact.

Lan Huang Ph.D.

“At BeyondSpring, patients are our “Northstar.” We aim to provide millions of cancer patients in need with transformative medicine, not only to extend their lives, but also to let them live with a good quality of life.”

Lan Huang Ph.D.

Lan Huang Ph.D., Co-founder & Chairman, BeyondSpring

Dr. Jen Majeti

“BEYONDSPRING’s rigorous approach to science, paired with a strategic vision, gives me great confidence that our capital is fueling innovations that will make a lasting impact on global health.”

Dr. Jen Majeti

Dr. Jen Majeti, Board Member of BeyondSpring

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