Overview

Indication/Target
Program
Stage
Trial Name / Collaborator
Plinabulin + Docetaxel
Study 103 (DUBLIN-3)

– OS, PFS, ORR benefit

Han et al., Lancet Resp Med 12(10): 775-786 (2024)

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Plinabulin alone or+ Pegfilgrastim
Studies 105 & 106

(PROTECTIVE-1 & PROTECTIVE-2)

Blayney et al. JAMA Oncol 6 (11): e204429 (2020)

Blayney et al. JAMA Network Open 5(1): e2145446 (2022)

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Plinabulin + Pembrolizumab + Docetaxel
Study 303
Plinabulin + Pembrolizumab + Etoposide/Platinum
Plinabulin + PD-1/PD L1 + Radiation
NCT04902040

Lin et al., Med 6(10):100752 (2025)

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Plinabulin + ADC with topoisomerase inhibitors (TOP1-ADC)

Late stage

Indication/Target
Program
Stage
Trial Name
Plinabulin + Docetaxel
Study 103 (DUBLIN-3)

Presented at ESMO Asia & NACLC 2025, ISLAC & ESMO 2024
Published in “LANCET Respiratory Medicine” – 2024

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Plinabulin + Docetaxel
Studies 105 & 106

(PROTECTIVE-1 & PROTECTIVE-2) JAMA Oncology 2020; JAMA Network 2022

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Investigator Initiated Trials

Indication/Target
Program
Stage
Trial Name
Plinabulin + Pembrolizumab + Docetaxel
Study 303

Presented at ASCO & SITC 2025

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Plinabulin + Pembrolizumab + Etoposide and Platinum
Study 302

Planned

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<p><span style="font-weight: 400;">Planned</span></p>
<p><a href="https://clinicaltrials.gov/study/NCT05745350" target="_blank" rel="noopener">Click here to read more</a></p>
Plinabulin + PD-1/PDL1 + Radiation
NCT04902040

Published in Med (Cell Press) 2025, Presented at SITC 2024 and 2025

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Plinabulin + ADC with topoisomerase inhibitors (TOP1-ADC)

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