Our values

We create a respectable, supportive, and innovative environnement for our team to thrive and contribute with the ultimate goal of extending lives and improving human health in a unique way.

Milestones in Our Journey

Explore the significant milestones that have shaped our company. Each event marks a step towards our mission of advancing cancer therapies.

2010

BeyondSpring Founded

Plinabulin Clinical Development Begins

2014

Phase 2 Anti-Cancer Proof of Concept

2015

DUBLIN-3 Phase 3 Initiated

2017

NASDAQ Listing (BYSI)

CIN Clinical Program Launched

2019

Plinabulin–Tubulin Crystal Structure Solved (Chem, 2019)

Plinabulin Novel MoA Elucidated: DC Maturation (Cell Reports, 2019 )

2020

Positive Phase 3 CIN Results

2021

Positive Topline DUBLIN-3 Phase 3 Results

2023

Preclinical-to-Clinical Translation of DC Maturation in Post-ICI Studies (SITC 2023)

2024

DUBLIN-3 Published in The Lancet Respiratory Medicine

Promising Post-ICI NSCLC Data (SITC 2024)

2025

Clinical PoC of DC Maturation Published;

GEF-H1 Immune Activation Gene Signature Validated (Med, 2025)

2026

DUBLIN-4 Confirmatory Phase 3 Planned

We advance first-in-class agent Plinabulin with a transformative potential in anti-cancer treatment through novel mechanisms and rigorous clinical development.

Founded in 2010, BeyondSpring Pharmaceuticals has made significant strides in developing potentially groundbreaking cancer therapies. Our commitment to innovation has led to key milestones, including the advancement of our lead asset, plinabulin, which aims to transform cancer care.

First-in-class brain-penetrant immune modulator with a differentiated mechanism and emerging clinical benefit across select tumor types.
Plinabulin at a glance

First-in-class brain-penetrant immune modulator with a differentiated mechanism and emerging clinical benefit across select tumor types.

By binding to a differentiated pocket in tubulin, Plinabulin transiently destabilizes microtubules and releases a key immune regulatory protein GEF-H1, which leads to activation of the RhoA/ROCK pathway, giving rise to dendritic cell maturation, enhanced antigen presentation and T cell activation. Dendritic cells are potent antigen- presenting cell that acts as the bridge between innate immunity and adaptive immunity. Plinabulin displays a dural clinical benefit in extending overall survival and significantt reduction of severe neutropenia of chemotherapy.

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