Plinabulin at a glance
First-in-class brain-penetrant immune modulator with a differentiated mechanism and emerging clinical benefit across select tumor types.
By binding to a differentiated pocket in tubulin, Plinabulin transiently destabilizes microtubules and releases a key immune regulatory protein GEF-H1, which leads to activation of the RhoA/ROCK pathway, giving rise to dendritic cell maturation, enhanced antigen presentation and T cell activation. Dendritic cells are potent antigen- presenting cell that acts as the bridge between innate immunity and adaptive immunity. Plinabulin displays a dural clinical benefit in extending overall survival and significantt reduction of severe neutropenia of chemotherapy.