We advance first-in-class agent Plinabulin with a transformative potential in anti-cancer treatment through novel mechanisms and rigorous clinical development.

Founded in 2010, BeyondSpring Pharmaceuticals has made significant strides in developing potentially groundbreaking cancer therapies. Our commitment to innovation has led to key milestones, including the advancement of our lead asset, plinabulin, which aims to transform cancer care.

First-in-class brain-penetrant immune modulator with a differentiated mechanism and emerging clinical benefit across select tumor types.
Plinabulin at a glance

First-in-class brain-penetrant immune modulator with a differentiated mechanism and emerging clinical benefit across select tumor types.

By binding to a differentiated pocket in tubulin, Plinabulin transiently destabilizes microtubules and releases a key immune regulatory protein GEF-H1, which leads to activation of the RhoA/ROCK pathway, giving rise to dendritic cell maturation, enhanced antigen presentation and T cell activation. Dendritic cells are potent antigen- presenting cell that acts as the bridge between innate immunity and adaptive immunity. Plinabulin displays a dural clinical benefit in extending overall survival and significantt reduction of severe neutropenia of chemotherapy.

Leadership

Meet leadership, board, and advisors

Meet the dedicated professionals driving our mission.

Lan Huang, Ph.D.
Lan Huang, Ph.D.

Co-founder, Chairman & Chief Executive Officer

June Lu, Ph.D.
June Lu, Ph.D.

Chief Scientific Officer

John Mao, Ph.D.
John Mao, Ph.D.

SVP, Development

Helen Li, M.D
Helen Li, M.D

VP, Clinical Science

Hao Zhang
Hao Zhang

Senior Director of Chemical Manufacturing Control (CMC)

Joy Jia
Joy Jia

VP, Finance

Qi Liu M.D., Ph.D.

Medical Consultant

Lan Huang, Ph.D.
Lan Huang, Ph.D.

Co-founder, Chairman & Chief Executive Officer

Sihai Xu, M.B.A.
Sihai Xu, M.B.A.

Director

Jiangwen (Jen) Majeti, Ph.D., M.B.A.

Director

Matthew Kirkby, M.A.

Director

Patrick Fabbio

Director

Brendan Delaney

Director

Trevor Feinstein, M.D.
Trevor Feinstein, M.D.

Piedmont Cancer Institute

Stephen Lin, M.D.
Stephen Lin, M.D.

MD Anderson Cancer Center

John Ruckdeschel, M.D.
John Ruckdeschel, M.D.

Fox Chase Cancer Center

Adam Grippin, M.D., Ph.D.
Adam Grippin, M.D., Ph.D.

MD Anderson Cancer Center

We're Hiring
We're Hiring

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leadership

Milestones in Our Journey

Explore the significant milestones that have shaped our company. Each event marks a step towards our mission of advancing cancer therapies.

2010

Company Founded

BeyondSpring Pharmaceuticals was established to innovate cancer treatment solutions. Our journey began with a commitment to improving patient outcomes.

2015

Anti-cancer Clinical Trials Begin

We initiated Dublin-3 phase 3 clinical trials for plinabulin and docetaxel combination, aiming to validate its anti-cancer efficacy in second- and third-line EGFR wild-type NSCLC compared to standard of care docetaxel. This step brought us closer to our goal of advancing cancer treatment options.

2017

Chemotherapy-induced neutropenia (CIN) Clinical Trials Begin

We initiated 4 clinical trials to explore plinabulin’s effect in reducing chemotherapy-induced neutropenia in NSCLC, prostate cancer, and breast cancer.

2019

Novel Mechanism Publication

We published plinabulin’s unique binding to tubulin, and its potent DC maturation mechanism (via GEF-H1) in two Cell Press journals after multi-year efforts. This marked a pivotal moment in our research and development efforts to enrich patients for Plinabulin mechanism-targeted indications.

2021

Target Cancer Patients who Failed prior ICI

With our understanding of Plinabulin’s unique mechanism in DC maturation, we started multiple investigator-initiated studies in various cancers with patients after prior ICI failure, collaborating with leading institutions including MD Anderson Cancer Center and, Peking Union Hospital.

Our values

We create a respectable, supportive, and innovative environnement for our team to thrive and contribute with the ultimate goal of extending lives and improving human health in a unique way.

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Please contact us at HR@beyondspringpharma.com

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